Table 2.
Incidences of neoplastic lesions with pathological subtypes in the lungs of ferrets with or without NNK exposure for 24 - 32 weeksa).
| Group | NNK (mg/kg BW) |
Time (weeks) |
n | Neoplastic lesions |
No. of neoplastic lesion subtypes |
||||
|---|---|---|---|---|---|---|---|---|---|
| Positive animal | % Incidence | ADCb) | SQCc) | ADSQCd) | Le) | ||||
| 1 | None | 26 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
|
| |||||||||
| 2 | 200 | 24 | 6 | 1 | 16.7 | 1 | 0 | 0 | 0 |
|
| |||||||||
| 3 | 200 | 26 | 10 | 4 | 40.0 | 3 | 1 | 1 | 0 |
|
| |||||||||
| 4 | 200 | 32 | 6 | 4 | 66.7 | 2 | 1 | 0 | 1 |
a)
Including the data of dead animals during the experiment period. Some ferrets developed more than one type of pathologic lesions.
b)
ADC: Adenocarcinoma.
c)
SQC: Squamous cell carcinoma.
d)
ADSQC: Adenosquamous carcinoma.
e)
L: Lymphoma.