Table 3.
Comparison of the incidence of lung preneoplastic and neoplastic lesions in ferrets treated with NNK and/or exposed to cigarette smoke by present and previous studies.
| Treatment | Time (weeks) |
n | Preneoplastic Lesionsa) (% Incidence) |
Neoplastic Lesionsb) (% Incidence) |
Ref. | |
|---|---|---|---|---|---|---|
| NNK (mg/kg BW) |
Smoking Exposure (min/d) |
|||||
| 200 | None | 24 | 6 | 100 % | 16.7 % | Present study |
| 200 | None | 26 | 10 | 100 % | 40.0 % | Present study |
| 200 | None | 32 | 6 | 83.3 % | 66.7 % | Present study |
| 200 | 15 | 22 | 16 | 87.5 % | 25.0 % | 30 |
| 200 | 60 | 24 | 12 | 83.3 % | 50.0 % | 14 |
| None | 60 | 6 | 9 | 44.4 % | NDc) | 31 |
| None | 120 | 24 | 6 | 33.3 % | NDc) | 31 |
| None | 120 | 24 | 8 | 62.5 % | NDc) | 32 |
| None | 120 | 9 | 6 | 100 % | NDc) | 17, 38 |
a)
Including squamous dysplasia, squamous metaplasia and atypical adenomatous hyperplasia.
b)
Including adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma and lymphoma.
c)
ND: not detected.