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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Glia. 2013 Jul 8;61(9):1456–1470. doi: 10.1002/glia.22534

Figure 2. PAR1 is necessary for Klk6-induced oligodendrogliopathy in primary oligodendrocytes.

Figure 2

O4+ oligodendrocyte cultures from PAR1+/+, PAR1−/− or PAR2−/− mice were treated with active recombinant Klk6 for 24 h. A, B, Klk6 (30 nM) promoted significant process retraction in PAR1+/+ (SNK, p = 9.0 × 10−4) or PAR2−/− (SNK, p = 0.002) oligodendrocytes, but not in the absence of PAR1−/−. C, Klk6 treatment had no significant effect on oligodendrocyte number in cultures isolated from either PAR1+/+, PAR1−/− or PAR2−/− mice. Error bars indicate SEM. *p = < 0.005, **p = < 0.001, SNK. Scale bar = 100 μm.