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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Annu Rev Microbiol. 2012 Jun 28;66:325–347. doi: 10.1146/annurev-micro-092611-150039

Figure 2. Diversity of two-component signaling gene content in bacterial genomes.

Figure 2

(a) Plot showing the number of histidine kinases and response regulators in a range of organisms. Generally, most genomes contain equal numbers of kinases and regulators, as pathways typically comprise a kinase and one cognate regulator. When the ratio is not 1:1, there are usually more kinases than regulators, suggesting that response regulators may sometimes integrate signals from multiple kinases. (b) Plot showing the number of two-component proteins as a function of genome size for the same organisms as in panel (a). Each plot is based on 504 bacterial genomes (22). A handful of well-studied and notable species are marked with red squares.