Table 3.
Expression of YAP and pYAP according to breast cancer phenotype
| Parameters | Total (N = 678) (%) | Luminal A (n = 280) (%) | Luminal B (n = 156) (%) | HER-2 (n = 67) (%) | TNBC (n = 175) (%) | P-value |
|---|---|---|---|---|---|---|
| YAP (T-Nu) | 0.181 | |||||
| Negative | 636 (93.8) | 261 (93.2) | 152 (97.4) | 62 (92.5) | 161 (92.0) | |
| Positive | 42 (6.2) | 19 (6.8) | 4 (2.6) | 5 (7.5) | 14 (8.0) | |
| YAP (T-Cy) | 0.011 | |||||
| Negative | 646 (95.3) | 265 (94.6) | 151 (96.8) | 59 (88.1) | 171 (97.7) | |
| Positive | 32 (4.7) | 15 (5.4) | 5 (3.2) | 8 (11.9) | 4 (2.3) | |
| YAP (S) | 0.002 | |||||
| Negative | 574 (84.7) | 246 (87.9) | 121 (77.6) | 51 (76.1) | 156 (89.1) | |
| Positive | 104 (15.3) | 34 (12.1) | 35 (22.4) | 16 (23.9) | 19 (10.9) | |
| pYAP (T-Cy) | 0.049 | |||||
| Negative | 541 (79.8) | 224 (80.0) | 129 (82.7) | 45 (67.2) | 143 (81.7) | |
| Positive | 137 (20.2) | 56 (20.0) | 27 (17.3) | 22 (32.8) | 32 (18.3) | |
| pYAP (T-Nu) | 0.449 | |||||
| Negative | 672 (99.1) | 279 (99.6) | 155 (99.4) | 66 (98.5) | 172 (98.3) | |
| Positive | 6 (0.9) | 1 (0.4) | 1 (0.6) | 1 (1.5) | 3 (1.7) | |
| pYAP (S) | <0.001 | |||||
| Negative | 615 (90.7) | 261 (93.2) | 129 (82.7) | 57 (85.1) | 168 (96.0) | |
| Positive | 63 (9.3) | 19 (6.8) | 27 (17.3) | 10 (14.9) | 7 (4.0) |
TNBC, triple negative breast cancer.