Figure 4.

Effect of lead and cadmium on the TEM of liver of rats after administration for 90 days. Panel A: Normal liver, rat. Relationship of the hepatic cell to the sinusoids and characteristic organelles are seen. The bile canaliculus is located between adjoining cells, × 2550. Panel B: Detail of hepatic cell. Note ER fractured and membrane surface ribosome fallen off, marked intracellular edema and swollen disorganized mitochondria, × 2550. Nucleus (N), Mitochondria (m), Bile canaliculus (BC), Lysosomes (L), Ribosome (R), Rough endoplasmic reticulum (RER), Endoplasmic reticulum (ER).