Table 3.
Cox regression analysis to determine factors independently associated with unfavorable prognosis
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
|
|
||||
| Clinical parameter | * P value | Hazard ratio (95% CI) | * P value | Hazard ratio (95% CI) |
| Age (year) | 0.256 | 1.274 (0.839-1.937) | 0.666 | 1.098 (0.717-1.682) |
| Gender | 0.728 | 1.089 (0.673-1.762) | 0.809 | 1.063 (0.646-1.749) |
| Differentiation grade | 0.757 | 1.055 (0.750-1.485) | 0.619 | 0.911 (0.631-1.315) |
| Invasive depth | 0.475 | 1.442 (0.529-3.931) | 0.353 | 1.622 (0.584-4.502) |
| Lymph node metastasis | < 0.001 | 2.945 (1.908-4.545) | < 0.001 | 2.857 (1.824-4.476) |
| GRB2 expression | 0.022 | 1.657 (1.075-2.554) | 0.065 | 1.514 (0.974-2.355) |
*
P value, significance level is 0.05;
CI, confidence interval.