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. 2014 May 15;7(6):2743–2757.

Figure 6.

Figure 6

IL-33 from ectopic ESCs altered macrophage phagocytosis in ESC-macrophage units. The direct co-culture unit was treated with rIL-33 (10 ng/ml) or sST2 (100 ng/ml) for 48 h. Ectopic ESCs suppressed the phagocytic ability of monocyte-derived macrophages through higher expression of IDO1, while sST2 reversed this effect. Herein, Normal ESC: ESC from endometriosis-free patients; Ectopic ESC: ESC from endometriosis-derived endometriotic tissue; IDO1 interference: ectopic ESC transfected with SD11-IDO1 shRNA; Phagocytic cells (%): the ratio of macrophages that ingested fluorescent beads. Representative data are shown as well as the means ± SD of 15 different experiments. *P<0.05; **P<0.01.