Figure 1.

Schematic representation of individual isoforms of CaMKII variants. CaMKIIα and CaMKIIβ differ most in the variable region (They are products of different genes and have minor differences in the kinase and association domain which are not represented in this figure). Exon/intron structures of the CaMKIIα and β gene locus coding for the variable regions are shown in bottom. The variable region of CaMKIIα contains only exon 2 (E2) and exon 5 (E5). Both of these two exons are also presented in CaMKIIβ. Exon 3 (E3) is not identified in CaMKIIα but is contained in all CaMKIIβ variants. In CaMKIIβ variants, WT CaMKIIβ has all five axons. CaMKIIβ’ contains exon 1 (E1), E2, E3 and E5, but not exon E4. While CaMKIIβe lacks E1. E1 and E4 do not present in CaMKIIβ’e.