Table 2.
Cox regression analysis of prognostic factors in hepatocellular carcinoma
| Variables | OS | RFS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
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|
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| Unadjusted analysisa | Adjusted analysisb | Unadjusted analysisa | Adjusted analysisb | |||||||
|
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|
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| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||
| MICA expression | 0.695 (0.408-1.184) | 0.181 | 1.094 (0.592-2.022) | 0.774 | 0.928 (0.617-1.395) | 0.720 | 1.425 (0.896-2.267) | 0.135 | ||
| Gender | 1.021 (0.531-1.963) | 0.951 | 1.284 (0.629-2.620) | 0.492 | 1.046 (0.612-1.789) | 0.869 | 1.323 (0.743-2.355) | 0.342 | ||
| Age_class | 1.009 (0.607-1.678) | 0.972 | 1.106 (0.633-1.931) | 0.723 | 1.095 (0.735-1.633) | 0.655 | 1.120 (0.727-1.725) | 0.608 | ||
| HBsAg | 0.877 (0.214-3.598) | 0.855 | 0.893 (0.282-2.822) | 0.847 | ||||||
| AFP_class | 2.040 (1.224-3.399) | 0.006 | 1.875 (1.031-3.410) | 0.039 | 1.712 (1.148-2.554) | 0.008 | 1.749 (1.100-2.780) | 0.018 | ||
| HCC_size | 2.489 (1.401-4.421) | 0.002 | 1.769 (1.163-2.691) | 0.008 | ||||||
| Tumor_No | 2.273 (1.334-3.871) | 0.003 | 2.129 (1.385-3.272) | 0.001 | ||||||
| Differentiation | 1.717 (1.026-2.876) | 0.040 | 1.396 (0.801-2.433) | 0.240 | 1.647 (1.109-2.447) | 0.013 | 1.463 (0.963-2.223) | 0.074 | ||
| TNM | 1.953 (1.524-2.503) | 0.000 | 1.943 (1.489-2.536) | 0.000 | 1.661 (1.364-2.022) | 0.000 | 1.688 (1.368-2.083) | 0.000 | ||
| PVTT | 4.564 (2.527-8.244) | 0.000 | 3.869 (2.320-6.452) | 0.000 | ||||||
| therapy | 0.722 (0.366-1.424) | 0.347 | 0.632 (0.304-1.313) | 0.219 | 0.722 (0.432-1.205) | 0.212 | 0.597 (0.344-1.038) | 0.067 | ||
a
Hazard ratios in univariate models.
b
Hazard ratios in multivariable models.
Abbreviations: CI, confidence interval; MICA, MHC class I polypeptide-related sequence A; HR, hazard ratio; OS, overall survival; RFS, relapse-free survival; PVTT, Portal Vein Tumor Thrombus.