Table 2.

Animal olfactory behavioral studies

Study	AD Model	Age	Task	Result
Cassano et al. 2011	3xTg	18 months	Odor discrimination, social behavior	Intact discrimination, impaired social transmission
Girard et al. 2013	5xFAD	2-,4-,6-months	Olfactory delayed alternation and reversal	Deficits at 4 months
Phillips et al. 2011	APP/PS1	6–8 months	Odor versus visuospatial sensitivity and discrimination	Intact olfaction, impaired visuospatial
Montgomery et al. 2011	APP/PS1	12 months	Odor sensitivity, learning, spatial memory	Intact odor sensitivity, deficient learning, intact spatial memory
Wu et al. 2013	APP/PS1	1–10 months	Odor sensitivity, spatial memory	Decreased sensitivity at 3–4 months and deficient spatial memory at 9–10 months
Young et al. 2009	Tg2576	4–12 months	Olfactory working memory	Deficits as early as 4 months, worse with age
Deacon et al. 2009	Tg2576	Up to 23months	Odor sensitivity, social memory	Normal sensitivity, deficits in social memory
Guerin et al. 2009	Tg2576	6.5–8 months	Odor detection, habituation, associative learning	Normal detection and associative learning, impaired habituation due to short-term memory deficit
Wesson et al. 2010	Tg2576	3–29 months	Odor habituation	Habituation deficit at 3–4 months, increased investigation time at 16 months
Wesson et al. 2011	Tg2576	3 months+	Odor habituation	Deficit at 6–7 months