Skip to main content
. 2014 Jun 2;3:121. [Version 1] doi: 10.12688/f1000research.4188.1

Figure 3. Human UBA1 primary gene interaction network.

Figure 3.

Human orthologs of yeast genes identified from four independent SGA screens were used to map the corresponding protein-protein interaction network. Only proteins that have experimentally verified data (STRING) supporting a physical interaction with at least two additional genes/proteins identified in the UBA1-SGA screens are displayed. Of particular interest is the discovery of NEDD4, CUL3, GSK3, SUMO and HDAC in distinct network clusters. Proteins of interest are highlighted by a larger node size and indicated with an arrow.