Fig. 5.
Basal levels of calcineurin (a) and BDNF (b) in CA1 area. Exogenous administration of Aβ1–42 peptides increased the basal levels of calcineurin protein but did not affect BDNF protein levels. Moderate treadmill exercise prevented the aberrant up-regulation of calcineurin induced in Aβ rats as its basal levels in Ex/Aβ rats are similar to those of control and exercise rats. The basal levels of BDNF in exercised rats including Ex/Aβ rats were significantly increased compared to those of Aβ and control rats. (*) indicates significant difference compared to all groups (p<0.05). (#) indicates significant difference compared to control and exercise groups (p<0.05–0.01). Values are mean±S.E.M., n=4–6 rats/group. Insets are representative blots.