TABLE 1.

Genes differentially expressed in wild-type M. avium subsp. paratuberculosis and M. avium subsp. paratuberculosis ΔsigL during growth in Middlebrook 7H9 broth at an OD₆₀₀ of 0.5

Gene	Gene product; possible function	M. tuberculosis ortholog	% protein similarity to M. tuberculosis	Fold changea
pks10	Polyketide synthase; possible involvement in mycobacterial cell wall maintenance	Rv1660	82.2	3.5 ± 1.2
pks7	Polyketide synthase; possible involvement in mycobacterial cell wall maintenance	Rv1661	70.0	1.4 ± 0.1
lprL	Mce family protein; involved in host cell invasion	Rv0593	88.7	1.9 ± 0.2
MAP4089	Mce family protein; involved in host cell invasion	Rv0594	82.6	2.1 ± 0.7
MAP2635c	MMPL family protein; may be involved in lipid transport	Rv1145	89.1	2.4 ± 0.3
MAP3220c	Hypothetical; possible transmembrane protein	Rv3166c	55.1	1.2 ± 0.2
mpt53	Secreted protein; homologous to DsbE (involved in protein folding)	Rv2878c	89.8	26.2 ± 0.9
MAP2941c	Homologous to cytochrome c biogenesis protein; could be involved in membrane transport	Rv2877c	55.9	1.6 ± 0.3

^aValues are means ± standard deviations and are representative of two independent experiments. A change was considered significant for genes with a ≥±1.5-fold change and a level that was >2× the standard deviation.