TABLE 2.
Expression of chemokine genes in human macrophages infected in vitro with L. panamensis
| Gene | Avg fold change in gene expression compared to uninfected macrophages ± SD (range)a |
|
|---|---|---|
| L. panamensis from patients with chronic disease (n = 5) | L. panamensis from patients with self-healing disease (n = 4) | |
| CCL13 | 4.2 ± 2.7 (1.8–7.7) | 1.6 ± 0.7 (0.9–2.5) |
| CCL2 | 6.5 ± 0.9 (5.7–7.9)* | 1.5 ± 0.7 (0.6–2.3) |
| CCL25 | 3.6 ± 1.7 (2.2–6.6) | 2.1 ± 1.3 (0.3–3.5) |
| CCL7 | 4.7 ± 1.7 (3.2–6.9)* | 1.8 ± 1.2 (0.5–3.0) |
| CCL8 | 14.1 ± 4.0 (10.2–19.6)* | 1.8 ± 1.0 (0.9–3.2) |
| CXCL1 | 8.1 ± 1.8 (5.3–10.2)* | 2.0 ± 1.1 (0.8–3.3) |
| CXCL10 | 6.1 ± 2.8 (3.6–10.0)* | 1.1 ± 0.1 (0.9–1.2) |
| CXCL11 | 4.2 ± 2.1 (1.7–6.8)* | 0.8 ± 0.2 (0.6–1.1) |
| CXCL2 | 9.3 ± 2.9 (5.4–16.5)* | 2.3 ± 1.1 (1.2–3.4) |
| CXCL3 | 14.7 ± 5.2 (7.7–21.5)* | 2.4 ± 1.2 (1.1–4.0) |
| CXCL5 | 10.4 ± 4.9 (4.9–17.4)* | 1.6 ± 1.4 (0.5–3.6) |
| CXCL8/IL-8 | 19.4 ± 12.0 (3.1–33.6)* | 3.5 ± 3.3 (0.5–7.3) |
| IL-1β | 8 ± 7.0 (1.7–19.4) | 1.5 ± 1.1 (0.5–3.0) |
| IL-10 | 3.9 ± 1.0 (2.8–5.7)* | 1.7 ± 0.1 (1.5–1.8) |
a
Values represent averages ± standard deviations (ranges) of fold changes over uninfected macrophages. *, P < 0.05 (P values obtained from independent analyses applying the Mann-Whitney U test).