FIG 10.

Higher levels of 14-3-3τ are associated with a higher metastatic rate and shorter survival. (A) Several published breast cancer data sets (33–38) were analyzed to determine the correlation between 14-3-3τ expression and breast cancer metastasis. Patients were ranked according to 14-3-3τ expression levels in their breast tumors and were equally divided into four groups (14-3-3τ levels, low < int 1 < int 2 < high) or three groups (14-3-3τ levels, low < int < high). The metastasis rate of each group at 1 year, 3 years, and 5 years after diagnosis was correlated (raw values are presented in Table 1). (B) Kaplan-Meier analysis of breast cancer patients according to 14-3-3τ expression levels. The 14-3-3τ expression levels and clinical outcomes of van de Vijver et al. and Desmedt et al. data sets (33, 38) were analyzed. Patients were ranked according to 14-3-3τ expression levels in their breast tumors and then equally divided into four groups as described for panel A. The numbers (N) of patients in each group are indicated below. A Wilcoxon test was used to evaluate the significance. The P values for the differences between the high group and the other groups are indicated.