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. 2014 Jul;88(14):7764–7775. doi: 10.1128/JVI.00748-14

FIG 6.

FIG 6

MHC-II KO mice immunized with inactivated or live attenuated influenza vaccines are not protected against lethal infection. (A) Body weight changes. (B) Survival rates. B6 WT and MHC-II KO mice that were either intranasally two times inoculated with live attenuated att.NL virus vaccine or intramuscularly boost immunized with inactivated Rg20 (Rg20i, 5 μg/mouse) were challenged with a lethal dose (5× LD50) of 2009 H1N1 virus (A/California/04/2009). B6-att.NL, B6 WT mice (n = 5) intranasally inoculated with live attenuated virus (att.NL); B6-Rg20i, B6 WT mice (n = 5) intramuscularly immunized with whole inactivated 2009 H1N1 virus (Rg20i); MHCII KO-att.NL, MHC-II KO mice (n = 4) intranasally inoculated with live attenuated virus (att.NL); MHCII KO-Rg20i, MHC-II KO mice (n = 5) intramuscularly immunized with whole inactivated 2009 H1N1 virus (Rg20i). P1 is between B6 and MHC-II KO-att.NL; P2 is between B6 and MHC-II KO-Rg20i. **, P < 0.01.