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. 2014 Jul;88(14):8129–8138. doi: 10.1128/JVI.00732-14

FIG 5.

FIG 5

Primary transmission of classical ovine scrapie in cytosolic VRQ PrP transgenic Drosophila. VRQ(cyt) PrP transgenic (squares) or 51D control flies (circles) crossed with either the Actin-GAL4 or Elav-GAL4 driver line were assessed for locomotor activity by a negative-geotaxis climbing assay following exposure at the larval stage to VRQ/VRQ scrapie-infected (filled symbols) or scrapie-free (open symbols and dashed lines) sheep brain homogenate. Actin-GAL4-VRQ(cyt) PrP flies did not contain the gene for RFP. The mean PI ± SD is shown for three groups of 15 flies of each genotype per time point (a total of 45 flies of each genotype). Statistical analysis of the linear regression plots was performed by one-way ANOVA and Tukey's honest significant difference test for post hoc analysis.