FIG 9.

Lack of response by Elav-driven AHQ PrP transgenic Drosophila to atypical scrapie. PrP transgenic or 51D control flies crossed with the Elav-GAL4 driver line were assessed for locomotor activity by a negative-geotaxis climbing assay following exposure at the larval stage to AHQ/AHQ scrapie-infected (closed squares and continuous line) or scrapie-free (closed circles and dashed line) sheep brain homogenate or PBS (closed triangles and dotted line). The mean PI ± SD is shown for three groups of 15 flies of each genotype per time point (a total of 45 flies of each genotype). Statistical analysis of the linear regression plots was performed by one-way ANOVA and Tukey's honest significant difference test for post hoc analysis.