TABLE 4.

Differences in T cell proliferation and activation between seminal CMV shedders and nonshedders

Characteristica	Value		Univariate P valueb
	Any CMV (n = 21)	No CMV (n = 28)
T cell proliferation
Ki67+ (% of CD4+ T cells) [median (IQR)]
Total	4.2 (3.4–6.9)	3.0 (2.4–4.3)	0.01
Naive	1.9 (1.3–2.7)	1.5 (1.1–2.6)	0.44
Central memory	3.9 (3.1–5.1)	3.0 (2.5–4.8)	0.1
Transitional memory	4.0 (3.4–5.4)	3.5 (2.3–4.9)	0.14
Effector memory	5.8 (3.8–10.2)	4.2 (3.3–5.1)	0.09
Ki67+ (% of CD8+ T cells) [median (IQR)]
Total	3.7 (2.5–7.1)	2.82 (2.3–3.9)	0.1
Naive	2.4 (1.5–5.1)	1.73 (1.0–2.6)	0.13
Central memory	4.2 (2.8–8.9)	3.1 (2.5–5.2)	0.13
Transitional memory	2.7 (2.2–6.8)	2.7 (1.9–4.4)	0.2
Effector memory	4.5 (2.2–5.9)	2.9 (2.2–4.0)	0.35
T cell activation
HLA-DR+ CD38+ (% of CD4+ T cells) [median (IQR)]
Total	3.1 (2.4–7.4)	2.5 (1.7–3.0)	<0.01
Naive	2.2 (1.2–3.5)	1.7 (1.0–2.3)	0.27
Central memory	2.4 (1.6–2.7)	1.9 (1.1–2.7)	0.21
Effector memory	5.8 (4.0–14.8)	3.8 (2.5–5.6)	0.02
Terminally differentiated	25.5 (9.2–33.1)	13.2 (6.8–28.3)	0.18
HLA-DR+ CD38+ (% of CD8+ T cells) [median (IQR)]
Total	20.3 (13.2–23.9)	15.6 (8.3–21.8)	0.25
Naive	10.3 (6.8–13.0)	11.4 (4.0–17.1)	0.71
Central memory	15.6 (11.0–21.0)	13.3 (6.62–17.5)	0.31
Effector memory	21.5 (12.1–24.5)	15.7 (7.2–22.4)	0.17
Terminally differentiated	25.1 (15.8–33.7)	24.3 (10.8–31.6)	0.57

^aSubsets were defined as naive (CD45RA⁺ CD27⁺ CCR7⁺), central memory (CD45RA⁻ CD27⁺ CCR7⁺), transitional memory (CD45RA⁻ CD27⁺ CCR7⁻ for proliferation only), effector memory (CD45RA^+/− CD27⁻ CCR7⁻), and terminally differentiated (CD45RA⁺ CD27⁻ for activation only) in CD4 and CD8 T cell subsets. Immunological data were available for a subset of 49 subjects.

^bUnivariate P values were determined using the Mann-Whitney Wilcoxon test. P values of ≤0.1 are in boldface.