FIG 1.

(A) gD2 MAb tree. The diagram shows gD antigenic sites and associated MAbs used in this study. The defining properties of MAbs within each branch of the tree are indicated. Antigenic sites are defined by groups of MAbs that compete with each other for gD binding. MAb group designations are shown in boxes. gD residues implicated in MAb binding are in parentheses below the group names. Representative MAbs are shown in large type below the group names. Virus-neutralizing MAbs are shown in boldface. Receptor-blocking MAbs are indicated by asterisks. (B) Two views of the gD structure rotated 180°. The locations of the epitopes of the MAbs listed in panel A are indicated.