FIG 5.

Peptide ELISA. Binding of human subject IgGs to peptides mimicking portions of the gD2 ectodomain. Absorbance values generated by matching preimmune IgGs were subtracted from the data plotted. (A) Reactivity with a peptide representing the N terminus of gD (residues 1 to 20). (B) Reactivity with a peptide representing the C terminus of gD (residues 262 to 281). (C) Structure of gD (space-filling model) in complex with HVEM (green ribbon structure) and nectin-1 (purple ribbon structure). The N-terminal gD peptide (residues 1 to 20) is colored red. (D) Same structures as in panel C rotated 90° to more clearly show the locations of gD residues 262 to 281 (colored green).