FIG 1.

Pathogenicity of PR8:NS1-GFP (H1N1) influenza virus in WT and importin-α7^−/− mice. WT (black squares; n = 10) or α7^−/− (red open squares; n = 10) mice were intranasally inoculated with 10⁶ PFU of PR8:NS1-GFP virus. Weight loss (A) and survival (B) were monitored for 14 days. Mice receiving PBS were used as controls (gray circles; n = 6). The data shown represent means ± the standard errors of the means. (C) Lungs were removed from WT or α7^−/− mice at 1, 3, and 6 h p.i. (n = 2) and on days 1, 3, and 6 p.i. (n = 5), and virus titers were determined by plaque assay.