TABLE 2.
Summary of amino acid changes in Nef during acute infectiona
| Subject | Amino acid changeb | Reversion to consensus |
|---|---|---|
| 01 | D38X | No |
| H40Y | No | |
| T133I | Yes | |
| R190K | Yes | |
| H192P/R | No | |
| M194V | No | |
| 02 | Q22P | No |
| D28E | No | |
| R184K | Yes | |
| 03 | R22P | No |
| H199Y | No | |
| 04 | P14L | No |
| E94Q | No | |
| I114 M | No | |
| H115Y | Yes | |
| H192R | No | |
| V194 M | Yes | |
| 05 | K105E/R | No |
| 06 | E93K | No |
| H102Y | Yes | |
| Q104P | No | |
| D108E | No |
a
Defined as a fixed substitution or dominant polymorphism (>50% of clones) appearing between the first and last time points.
b
Numbering according to the HXB2 reference sequence. X, any amino acid.