TABLE 3.
Replication of H6N1and H9N2 wt and ca viruses in respiratory tissues of African green monkeysa
| Virus | Day pi | Nasal turbinates |
Pharynx |
Larynx |
Trachea |
Lung |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of culture-positive AGMs/total no. of AGMsb | Individual or mean titer(s) ± SEc | No. of culture-positive AGMs/total no. of AGMsb | Individual or mean titer(s) ± SEc | No. of culture-positive AGMs/total no. of AGMsb | Individual or mean titer(s) ± SEc | No. of culture-positive AGMs/total no. of AGMsb | Individual or mean titer(s) ± SEc | No. of culture-positive AGMs/total no. of AGMsb | Individual or mean titer(s) ± SEc | ||
| H6N1 wt | 2 | 4/4 | 5.6 ± 0.3 | 4/4 | 5.4 ± 0.9 | 4/4 | 5.0 ± 0.6 | 4/4 | 5.2 ± 0.5 | 4/4 | 4.5 ± 0.4 |
| 4 | 4/4 | 5.5 ± 0.7 | 4/4 | 5.7 ± 0.8 | 4/4 | 5.0 ± 0.5 | 4/4 | 5.1 ± 0.5 | 4/4 | 4.0 ± 0.3 | |
| H6N1 ca | 2 | 2/4 | 2, 4.3 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 |
| 4 | 1/4 | 2.0 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | |
| H9N2 wt | 2 | 1/4 | 2.5 | 2/4 | 3.7, 5.5 | 2/4 | 2.5, 4.2 | 2/4 | 4.4, 3.7 | 4/4 | 2.9 ± 0.1 |
| 4 | 1/4 | 3.4 | 1/4 | 4.2 | 2/4 | 4.2, 3.2 | 2/4 | 3.7, 2.0 | 4/4 | 2.9 ± 0.4 | |
| H9N2 ca | 2 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 |
| 4 | 1/4 | 4.2 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | 0/4 | ≤1.5 | |
a
wt, wild type; ca, cold adapted.
b
Data represent numbers of AGMs with detectable virus titer (>1.5 log10 TCID50/g).
c
Titers are expressed as log10 TCID50/g; individual titers are presented in italics if only one or two AGMs were culture positive; mean titers are presented if more than three animals were culture positive. SE, standard error.