Table 1.

Effect of agonists (ACPD, DHPG, and APDC) on the amplitudes of evoked IPSCs (percentage of the 1st IPSC in control group) in V1

L4-L2/3	Effect of ACPD, % of the 1st Control IPSC			GDPβS in the Intracellular Solution, % of the 1st Control IPSC			Effect of DHPG, % of the 1st Control IPSC		Effect of APDC, % of the 1st Control IPSC
Average ±SE	Control	ACPD	Washout	Control	ACPD	Washout	Control	DHPG	Control	APDC	Washout
IPSC1	100	44.5 ± 11.2†	92.0 ± 12.6	100	43.9 ± 5.5*	68.5 ± 6.2	100	93.4 ± 7.0	100	48.7 ± 9.8†	71.3 ± 14.1
IPSC2	97.4 ± 8.4	44.1 ± 9.8‡	79.0 ± 12.1	80.0 ± 7.2	36.6 ± 2.9*	71.6 ± 8.4	73.9 ± 5.9	71.4 ± 8.8	76.7 ± 6.5	42.1 ± 8.7†	54.6 ± 10.7
IPSC3	84.7 ± 8.9	42.5 ± 9.2†	72.3 ± 11.6	70.0 ± 6.0	33.9 ± 3.3*	65.6 ± 7.6	61.2 ± 6.7	57.1 ± 7.1	67.5 ± 7.8	38.3 ± 7.2*	50.3 ± 8.4
IPSC4	73.1 ± 9.8	43.1 ± 7.4†	69.2 ± 11.0	64.0 ± 5.7	33.7 ± 3.4*	58.3 ± 7.9	52.0 ± 6.3	48.7 ± 6.1	60.6 ± 6.3	38.6 ± 6.1†	50.7 ± 5.8
L4-L4	Effect of ACPD, % of the 1st Control IPSC			GDPβS in the Intracellular Solution, % of the 1st Control IPSC			Effect of DHPG, % of the 1st Control IPSC		Effect of APDC, % of the 1st Control IPSC
Average ±SE	Control	ACPD	Washout	Control	ACPD	Washout	Control	DHPG	Control	APDC	Washout
IPSC1	100	38.8 ± 9.2‡	93.8 ± 8.7	100	49.5 ± 4.2*	97.7 ± 9.1	100	92.8 ± 5.6	100	47.3 ± 4.8‡	76.6 ± 6.7
IPSC2	96.6 ± 8.6	41.2 ± 7.3†	91.5 ± 8.8	100.3 ± 4.6	51.2 ± 4.9*	86.1 ± 9.8	101.9 ± 5.0	93.3 ± 2.2	94.8 ± 5.6	54.9 ± 3.6‡	65.6 ± 7.6
IPSC3	88.1 ± 10.1	41.4 ± 4.8†	89.7 ± 9.0	91.4 ± 3.6	53.3 ± 6.5*	77.6 ± 7.4	99.1 ± 4.0	93.8 ± 5.6	96.4 ± 6.7	57.5 ± 4.8‡	60.5 ± 7.9
IPSC4	86.7 ± 10.1	44.4 ± 6.6*	80.4 ± 9.8	83.8 ± 4.1	49.9 ± 5.6*	71.5 ± 7.2	89.5 ± 5.9	84.4 ± 4.2	85.8 ± 6.9	56.7 ± 4.0‡	60.3 ± 7.5

IPSCs, inhibitory postsynaptic currents; L, layer.

^*P < 0.05,

^†P < 0.01, and

^‡P < 0.001.