Table 1.
L4-L2/3 | Effect of ACPD, % of the 1st Control IPSC |
GDPβS in the Intracellular Solution, % of the 1st Control IPSC |
Effect of DHPG, % of the 1st Control IPSC |
Effect of APDC, % of the 1st Control IPSC |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Average ±SE | Control | ACPD | Washout | Control | ACPD | Washout | Control | DHPG | Control | APDC | Washout |
IPSC1 | 100 | 44.5 ± 11.2† | 92.0 ± 12.6 | 100 | 43.9 ± 5.5* | 68.5 ± 6.2 | 100 | 93.4 ± 7.0 | 100 | 48.7 ± 9.8† | 71.3 ± 14.1 |
IPSC2 | 97.4 ± 8.4 | 44.1 ± 9.8‡ | 79.0 ± 12.1 | 80.0 ± 7.2 | 36.6 ± 2.9* | 71.6 ± 8.4 | 73.9 ± 5.9 | 71.4 ± 8.8 | 76.7 ± 6.5 | 42.1 ± 8.7† | 54.6 ± 10.7 |
IPSC3 | 84.7 ± 8.9 | 42.5 ± 9.2† | 72.3 ± 11.6 | 70.0 ± 6.0 | 33.9 ± 3.3* | 65.6 ± 7.6 | 61.2 ± 6.7 | 57.1 ± 7.1 | 67.5 ± 7.8 | 38.3 ± 7.2* | 50.3 ± 8.4 |
IPSC4 | 73.1 ± 9.8 | 43.1 ± 7.4† | 69.2 ± 11.0 | 64.0 ± 5.7 | 33.7 ± 3.4* | 58.3 ± 7.9 | 52.0 ± 6.3 | 48.7 ± 6.1 | 60.6 ± 6.3 | 38.6 ± 6.1† | 50.7 ± 5.8 |
L4-L4 | Effect of ACPD, % of the 1st Control IPSC | GDPβS in the Intracellular Solution, % of the 1st Control IPSC | Effect of DHPG, % of the 1st Control IPSC | Effect of APDC, % of the 1st Control IPSC | |||||||
Average ±SE | Control | ACPD | Washout | Control | ACPD | Washout | Control | DHPG | Control | APDC | Washout |
IPSC1 | 100 | 38.8 ± 9.2‡ | 93.8 ± 8.7 | 100 | 49.5 ± 4.2* | 97.7 ± 9.1 | 100 | 92.8 ± 5.6 | 100 | 47.3 ± 4.8‡ | 76.6 ± 6.7 |
IPSC2 | 96.6 ± 8.6 | 41.2 ± 7.3† | 91.5 ± 8.8 | 100.3 ± 4.6 | 51.2 ± 4.9* | 86.1 ± 9.8 | 101.9 ± 5.0 | 93.3 ± 2.2 | 94.8 ± 5.6 | 54.9 ± 3.6‡ | 65.6 ± 7.6 |
IPSC3 | 88.1 ± 10.1 | 41.4 ± 4.8† | 89.7 ± 9.0 | 91.4 ± 3.6 | 53.3 ± 6.5* | 77.6 ± 7.4 | 99.1 ± 4.0 | 93.8 ± 5.6 | 96.4 ± 6.7 | 57.5 ± 4.8‡ | 60.5 ± 7.9 |
IPSC4 | 86.7 ± 10.1 | 44.4 ± 6.6* | 80.4 ± 9.8 | 83.8 ± 4.1 | 49.9 ± 5.6* | 71.5 ± 7.2 | 89.5 ± 5.9 | 84.4 ± 4.2 | 85.8 ± 6.9 | 56.7 ± 4.0‡ | 60.3 ± 7.5 |
IPSCs, inhibitory postsynaptic currents; L, layer.
P < 0.05,
P < 0.01, and
P < 0.001.