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DNA recognition by the resolvase/invertase family of serine recombinases. A: The γδ resolvase dimer (purple and yellow) in complex with target DNA (gray). PDB ID: 1GDT (Yang and Steitz, 1995). DBD indicates DNA-binding domain. B: Specific recognition of DNA (gray) by the serine recombinase arm region (sticks). Residues that confer catalytic domain specificity and have been subject to reprogramming are highlighted purple (Gaj et al., 2011, 2013b).
