. Author manuscript; available in PMC: 2015 Jul 1.

Published in final edited form as: World J Biol Psychiatry. 2013 Sep 30;15(5):404–410. doi: 10.3109/15622975.2013.832380

Table II.

Mean change in bone biomarkers (P1NP, CTX) by individual and combined genetic groups for 69 older adults treated with venlafaxine XR for 12 weeks.

	n	P1NP		CTX
	n	Mean change (SD)	Wilcoxon matched pair signed rank test P value	Mean change (SD)	Wilcoxon matched pair signed rank test P value
Serotonin transporter 5HTTLPR
High-expressing (LA = 1 or 2)	45	−4.1 (15.7)^*	0.02	22.6 (165.8)	0.22
Low-expressing (LA = 0)	22	−0.2 (19.8)	0.74	35.7 (0.1)	0.13
HRT1B receptor rs11568817 SNP
High-expressing (GG/GT)	45	−1.6 (18.4)	0.30	18.4 (185.5)	0.26
Low-expressing (TT)	21	−4.9 (13.0)^*	0.04	40.8 (185.5)	0.20
Combined genotypes
5HTTLPR high + HTR1B high	31	−2.4 (11.2)	0.27	7.2 (128.1)	0.75
5HTTLPR high + HTR1B low	13	−7.4 (10.4)^*	0.02	51.9 (94.9)	0.14
5HTTLPR low + HTR1B high	14	0.3 (10.8)	0.86	43.1 (90.8)	0.09

P < 0.05.