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. 2014 Jul 15;7:27. doi: 10.3389/fneng.2014.00027

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Copyright © 2014 Luan, Williams, Nikolic and Constandinou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) A cross-section of a myelinated nerve axon stimulated using an external stimulation electrode and an equivalent circuit model. (B) An AP generation in the nerve: simulation on the Neuron platform for AP generation with axon diameter of 15 μm, L = 1.5 mm, T = 23°C, stimulus = 300 μs, stimulus current of 147 μA. Lines show the extracellular (V_e) and membrane voltage (V_m = V_i − V_e, V_i is intracellular voltage) at the nodes 1, 2, and 3 shown in (A). For more details about the electrode-electrolyte model and the nerve model which is in this case Xenopus laevis sciatic nerve see Mou et al. (2012).