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. 2014 Jun 29;4(2):55–67. doi: 10.5681/bi.2014.021

Fig. 2 .

Fig. 2

Tumor interstitium and microcirculation. 1: Deformed/ damaged ECM allows invasion and metastasis. 2: Non-integrated tumor microvasculature with pores (120-1200 nm) results in high pressure in TIF, extravasation of macromolecules and enhanced permeability and retention of NPs. 3: Cancer microcirculation can be attained by lined-up epithelial cancer cells. 4: In the core of TME, colonies of untouched cancer cells are located, in which anticancer agents fail to reach these cells. TIF: Tumor interstitial fluid. ECM: extracellular matrix. NPs: nanoparticles.