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A: Compared with controls, there was significantly decreased whole brain FDG uptake (rSUV) in MCI and AD groups (P = 0.002) compared with controls. Note there was no significant difference of FDG rSUV between MCI and early AD group (P 0.71). There was significant correlation between FDG uptake and amyloid load averaged over the whole brain cerebral cortex in all three groups, shown in B (Pearson correlation r = 0.57; P ¼ 0.0006).
