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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Magn Reson Imaging. 2013 Dec 31;41(1):102–109. doi: 10.1002/jmri.24550

Figure 8.

Figure 8

A: Illustration of spatial correspondence among extracellular white matter inflammation, extracellular amyloid plaques, neuronal and trans-synaptic dysfunction (hypo-metabolism), and neurodegeneration (i.e., reduced neuronal activity) in early AD. B: Summary of results suggesting dynamic changes and correlations among four metrics from control to MCI to AD. The WMLL and amyloid deposition were significantly higher in AD and MCI patients compared to controls (P < 0.05), with a trend of higher degree in AD compared with MCI. The FDG uptake was lower in AD and MCI compared with controls (P < 0.002). The functional activity and connectivity was lower in MCI and AD compared with controls, while there was both decreased and increased functional activity in AD compared with MCI patients. Arrows indicate significant correlations (P < 0.05) between metrics within group: WMLL and fALFF in MCI group (purple arrow), amyloid and fALFF in AD group (red arrow), WMLL and amyloid load (all groups, blue), FDG uptake and amyloid load (all groups, cyan).