Table 6.
Comparison of ARF beam sequence sensitivity and specificity for plaque detection and characterization (measured ex vivo in porcine femoral arteries under simulated in vivo conditions) versus published sensitivity and specificity for MRI and CT (measured in vivo in human carotids) [40, 41].
| ARF-Based Ultrasound | CT | MRI | |||||
|---|---|---|---|---|---|---|---|
| (Ex vivo, procine femoral) | (In vivo, human carotid) | ||||||
| Detection | Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | |
| Type III-Va,b,c | 85% | 79% | - | - | 80–84% | 90–98% | |
| Type unreported | - | - | 88–95% | 90–96% | - | - | |
| Characterization | |||||||
| Calcium | 96%* | 85%* | 100% | 100% | 76–80% | 86–94% | |
| Lipid/soft | 80%* | 86%* | 76% | 74% | 91–98% | 65–100% | |
| Fibrous cap | 86%* | 82%* | - | - | 81% | 90% | |
| Degraded IEL | 92% | 75%* | - | - | - | - | |
| Collagen | 78%† | 77%† | 86% | 94% | - | - | |
Values marked with ‘*’are reported from SP3-SRx sequence results
Values marked with ‘†’ are reported from SP1.5-ParRx sequence results.