Skip to main content
. 2014 Feb 25;24(5):436–451. doi: 10.1111/bpa.12119

Figure 8.

figure

Central nervous system inflammation during the acute stage of Theiler's murine encephalomyelitis virus (TMEV) infection. Control TMEV‐infected mice (A, TMEV alone) had more inflammation (arrows) than mice treated with induced regulatory T cell (iTreg) (B, iTreg‐early). iTreg‐early mice had only a few cell infiltrates around dilated vessels (B, inset). Note no dilatation of vessels in uninfected mice (E inset, no infection). A,B,E. Luxol fast blue staining of the hippocampus of representative mice killed during the acute stage. C,D. Consecutive sections immunostained using CD3 antibody showed that iTreg‐early mice had few T cells around vessels, whereas control‐infected mice had a substantial T‐cell infiltration around vessels as well as in the parenchyma. F. Quantification of inflammation in the brain of TMEV‐infected mice showed that iTreg‐early mice (open bars) had significantly lower perivascular and overall inflammatory scores than control mice (closed bars) (*P < 0.05). The results are representative of two independent experiments. Magnifications ×18; insets ×74.