Figure 2.

Epigenomic features of expressed and silenced chromatin states. Genomic positions and patterns of various histone modifications are based on chromatin immunoprecipitation-sequencing–mediated epigenome mapping. Active genes are marked with H3K4me3 in their promoters and H3K36me3 in the gene body. Active enhancers are marked with H3K4me1 and H3K27 acetylation (ac). On the other hand, silenced genes have repressive H3K9me3 and H3K27me3 marks as well as DNA methylation in their promoter regions.