Figure 3.

Effects of systemic administration of a nonpenetrant OTR antagonist on food intake and weight gain. Six-hour fasted rats (n = 7–8/group) were given a single ip injection of vehicle or L-371,257 (0.5, 1.0 mg/kg) 30–45 minutes prior to the start of the dark cycle and access to food. A, Food intake was measured at 30 minutes, 3 hours, and 4 hours after access to food. B, BW was measured at 18 hours after access to food. Data are expressed as mean ± SEM (pairwise LSD comparisons). *, P < .05; †, 0.05 < P < .1).