Changes in histone acetylation in response to acute stress, CVS, or CVS plus novel acute stress within the hippocampus are subregion-specific. This figure shows quantification and representative Western blots of acetylation of lysine 12 on histone 4 relative to total histone 3 protein in the hippocampus of control, acutely stressed, CVS, and CVS plus acute stress. Data are shown as mean ± SE; *, P < .05; **, P < .01; ***, P < .001 (n = 5–6 animals per group).