Figure 2.

SgrS controls carbon metabolism and virulence factor production. The SgrS sRNA regulates the ptsG and manXYZ, yigL and sopD mRNAs via direct base-pairing with the respective transcripts. Activation of yigL requires inhibition of endonucleolytic degradation through sequestration of a RNase E cleavage site. The ptsG and manXYZ mRNAs encode carbohydrate transporters for glucose and mannose, respectively. The yigL gene encodes a potent phosphatase which removes phosphate residues from intracellular carbohydrates which allows export. The sopD gene is specific to Salmonella and its translation results in a secreted virulence factor that enters the mammalian host cell.