Table 3:

Univariate and Multivariate Linear Regression Models for Mean C_T Value among Xpert Positives and Log Time to Culture Positivity among Individuals with Culture-Positive Tuberculosis

	Outcome: Mean CT Value				Outcome: Log Time to Culture Positivity
	Univariate		Multivariate		Univariate		Multivariate
	β Coefficient (95% CI)	P Value	β Coefficient (95% CI)	P Value	β Coefficient (95% CI)	P Value	β Coefficient (95% CI)	P Value
Sex
Male	REF		REF		REF		REF
Female	0.64 (−0.57 to 1.86)	0.300	−0.81 (−2.03 to 0.40)	0.186	0.13 (0.028 to 0.24)	0.014	−0.20 (−0.12 to 0.79)	0.691
Age category
≤35	REF		REF		REF		REF
>35	0.20 (−1.02 to 1.41)	0.750	0.47 (−0.72 to 1.65)	0.4	−0.010 (−0.11 to 0.096)	0.844	0.01 (−0.08 to 0.11)	0.776
Site
Johannesburg	REF		REF		REF		REF
Cape Town	−3.42 (−4.59 to −2.25)	<0.001	−1.24 (−2.57 to 0.60)	0.086	−0.57 (−0.66 to −0.47)	<0.001	−0.27 (−0.46 to 0.36)	0.0.98
HIV
Negative	REF		REF		REF		REF
HIV+, CD4 ≥ 200	1.99 (0.38 to 3.59)	0.015	1.50 (−0.13 to 3.14)	0.071	0.35 (0.22 to 0.48)	<0.001	0.21 (0.08 to 0.33)	0.001
HIV+, CD4 < 200	4.62 (3.28 to 5.97)	<0.001	3.66 (2.17 to 5.16)	<0.001	0.41 (0.29 to 0.53)	<0.001	0.22 (0.10 to 0.34)	<0.001
ART use
Not on ART	REF				REF
On ART	1.90 (−3.49 to 7.29)	0.473			0.28 (−0.10 to 0.65)	0.141

Definition of abbreviations: ART = antiretroviral treatment; CI = confidence interval; C_T = cycle threshold; REF = reference; Xpert = Xpert MTB/RIF.