Table 2:
Top 10 Signaling Pathways Represented by the 319 Differentially Regulated Gene Probes
| Signaling Pathway | Number of Genes | P Value |
|---|---|---|
| T-cell receptor signaling | 11 | 1.9 × 10−8 |
| iCOS-iCOSL signaling in T-helper cells | 10 | 2.9 × 10−7 |
| Role of NFAT in regulation of the immune response | 12 | 5.7 × 10−7 |
| CD28 signaling in T helper cells | 10 | 7.2 × 10−7 |
| PKCθ signaling in T lymphocytes | 9 | 6.3 × 10−6 |
| CCR5 signaling in macrophages | 7 | 1.0 × 10−5 |
| CTLA4 signaling in cytotoxic T lymphocytes | 7 | 6.3 × 10−5 |
| Glucocorticoid receptor signaling | 12 | 7.3 × 10−5 |
| iNOS signaling | 5 | 1.7 × 10−4 |
| Nur77 signaling in T lymphocytes | 5 | 2.1 × 10−4 |
Definition of abbreviations: CCR = chemokine receptor; CTLA = cytotoxic T- lymphocyte antigen; iCOS = inducible T-cell costimulator (CD278); iNOS = inducible nitric oxide synthetase; NFAT = nuclear factor of activated T cells; PKC = protein kinase C.