Table 5:
Statistical Analysis of Genotype Association with Clinical Category
| Unaffected Carriers | All Control Subjects | |
|---|---|---|
| VNTR alleles* | ||
| All PAH | 0.053 | 0.028 |
| Unaffected carriers | ns | |
| SNP3 Y185 genotypes* | ||
| All PAH | ns | 0.025 |
| Unaffected carriers | ns | |
| SNP4 C325A genotypes† | ||
| All PAH | 0.019 | ns |
| Unaffected carriers | 0.050 |
Definition of abbreviations: ns = not significant; PAH = pulmonary arterial hypertension; PGIS = prostacyclin synthase; SNP = single-nucleotide polymorphism; VNTR = variable number of tandem repeats.
*
Chi-square test.
†
Fisher exact test.