Table 6:

PGIS Promoter VNTR, SNP3, and SNP4 Genotype Association with PAH Risk

	Odds Ratio	95% CI	Chi-Square Test	P Value
SNP1 K22 Genotypes*†
G/T vs. G/G	0.85	0.42–1.72	0.21	ns
T/T vs. G/G	0.52	0.24–1.11	2.87	0.090
SNP3 Y185 Genotypes*†
C/T vs C/C	1.11	0.60–2.04	0.12	ns
T/T vs C/C	0.40	0.18–0.87	5.40	0.020
SNP4 C325A Genotypes*‡
C/A+A/A vs C/C	0.27	0.10–0.72	7.36	0.007

Definition of abbreviations: CI = confidence interval; ns = not significant; PAH = pulmonary arterial hypertension; PGIS = prostacyclin synthase; SNP = single-nucleotide polymorphism; VNTR = variable number of tandem repeats.

^*Chi-square test.

^†Control subjects vs. all PAH.

^‡Unaffected carriers vs. all PAH.