TABLE 3.
Selected Increased Probe Sets in MG-Responsive Human Hepatocyte Cultures
| Fold change | |||||
|---|---|---|---|---|---|
| Probe set | Gene symbol | Description | Donor A | Donor B | Donor C |
| 206262_at | ADH1B | Alcohol dehydrogenase IB (class I), beta polypeptide | 5.657 | 1.625 | 3.031 |
| 204039_at | CEBPA | CCAAT/enhancer-binding protein (C/EBP), alpha | 2.297 | 1.866 | 1.866 |
| 209366_x_at* | CYB5 | Cytochrome b-5 | 1.866 | 1.516 | 1.320 |
| 203979_at | CYP27A1 | Cytochrome P450, family 27, subfamily A, polypeptide 1 | 2.462 | 1.625 | 1.625 |
| 211295_x_at* | CYP2A6 | Cytochrome P450, family 2, subfamily A, polypeptide 6 | 4.925 | 6.063 | 14.929 |
| 207718_x_at | CYP2A7 | Cytochrome P450, family 2, subfamily A, polypeptide 7 | 2.639 | 6.063 | 12.996 |
| 206754_s_at* | CYP2B6 | Cytochrome P450, family 2, subfamily B, polypeptide 6 | 1.414 | 9.849 | 8.574 |
| 216661_x_at* | CYP2C19 | Cytochrome P450, family 2, subfamily C, polypeptide 19 | 1.741 | 2.144 | 2.000 |
| 208147_s_at | CYP2C8 | Cytochrome P450, family 2, subfamily C, polypeptide 8 | 3.249 | 3.249 | 2.828 |
| 220017_x_at* | CYP2C9 | Cytochrome P450, family 2, subfamily C, polypeptide 9 | 1.625 | 2.000 | 1.866 |
| 205999_x_at* | CYP3A4 | Cytochrome P450, family 3, subfamily A, polypeptide 4 | 4.000 | 2.000 | 3.482 |
| 211442_x_at | CYP3A43 | Cytochrome P450, family 3, subfamily A, polypeptide 43 | 1.414 | 2.144 | 2.639 |
| 211843_x_at* | CYP3A7 | Cytochrome P450, family 3, subfamily A, polypeptide 7 | 2.828 | 1.866 | 3.031 |
| 202017_at | EPHX1 | Epoxide hydrolase 1, microsomal | 2.297 | 2.639 | 3.732 |
| 205776_at* | FMO5 | Flavin-containing monooxygenase 5 | 1.741 | 1.866 | 1.625 |
| 225768_at | NR1D2 | Nuclear receptor subfamily 1, group D, member 2 | 1.741 | 2.000 | 1.741 |
| 207007_at | NR1I3 | Nuclear receptor subfamily 1, group I, member 3 | 3.249 | 1.866 | 1.625 |
| 207097_s_at | SLC17A2 | Solute carrier family 17, member 2 | 1.866 | 2.144 | 1.414 |
| 201920_at | SLC20A1 | Solute carrier family 20, member 1 | 1.320 | 2.639 | 1.625 |
| 205972_at | SLC38A3 | Solute carrier family 38, member 3 | 3.249 | 2.144 | 1.866 |
| 225516_at | SLC7A2 | Solute carrier family 7, member 2 | 1.866 | 1.741 | 1.414 |
| 222071_s_at | SLCO4C1 | Solute carrier organic anion transporter family, member 4C1 | 1.866 | 1.625 | 3.031 |
| 203615_x_at | SULT1A1 | Sulfotransferase family, cytosolic, 1A, member 1 | 1.414 | 1.320 | 1.149 |
| 206292_s_at | SULT2A1 | Sulfotransferase family, cytosolic, 2A, member 1 | 1.625 | 1.516 | 1.625 |
Note. Microarray results were filtered for probe sets upregulated in Matrigel samples for donor A, donor B, and donor C. Amount of fold change compared to control for each probe set is reported. An asterisk (*) denotes those genes which had multiple probe sets increased; a single representative probe set with fold changes with respect to control is reported.