TABLE 5.
Selected Decreased Probe Sets in MG-Responsive Human Hepatocyte Samples
| Fold change | |||||
|---|---|---|---|---|---|
| Probe set | Description | Gene symbol | Donor A | Donor B | Donor C |
| 208636_at* | Actinin, alpha 1 | ACTN1 | 0.660 | 0.758 | 0.574 |
| 205289_at* | Bone morphogenetic protein 2 | BMP2 | 0.500 | 0.406 | 0.574 |
| 211367_s_at* | Caspase 1, apoptosis-related cysteine protease | CASP1 | 0.707 | 0.660 | 0.707 |
| 203065_s_at* | Caveolin 1, caveolae protein, 22 kDa | CAV1 | 0.435 | 0.406 | 0.574 |
| 203324_s_at | caveolin 2 | CAV2 | 0.660 | 0.616 | 0.812 |
| 208727_s_at | Cell division cycle 42 | CDC42 | 0.660 | 0.758 | 0.574 |
| 823_at | Chemokine (C-X3-C motif) ligand 1 | CX3CL1 | 0.707 | 0.758 | 0.536 |
| 204470_at | Chemokine (C-X-C motif) ligand 1 | CXCL1 | 0.406 | 0.660 | 0.500 |
| 206336_at | Chemokine (C-X-C motif) ligand 6 | CXCL6 | 0.406 | 0.574 | 0.435 |
| 200859_x_at* | Filamin A, alpha | FLNA | 0.308 | 0.707 | 0.616 |
| 210338_s_at | Heat shock 70-kDa protein 8 | HSPA8 | 0.871 | 0.812 | 0.812 |
| 201841_s_at | Heat shock 27-kDa protein 1 | HSPB1 | 0.536 | 0.707 | 0.536 |
| 221667_s_at | Heat shock 22-kDa protein 8 | HSPB8 | 0.354 | 0.574 | 0.536 |
| 202727_s_at* | Interferon gamma receptor 1 | IFNGR1 | 0.536 | 0.660 | 0.707 |
| 206295_at | Interleukin 18 | IL18 | 0.287 | 0.287 | 0.379 |
| 202859_x_at* | Interleukin 8 | IL8 | 0.218 | 0.616 | 0.536 |
| 202351_at | Integrin, alpha V | ITGAV | 0.500 | 0.758 | 0.616 |
| 1553530_a_at* | Integrin, beta 1 | ITGB1 | 0.574 | 0.467 | 0.707 |
| 226535_at | Integrin, beta 6 | ITGB6 | 0.354 | 0.467 | 0.500 |
| 1552611_a_at* | Janus kinase 1 | JAK1 | 0.616 | 0.574 | 0.707 |
| 201596_x_at | Keratin 18 | KRT18 | 0.758 | 0.812 | 0.536 |
| 201650_at | Keratin 19 | KRT19 | 0.435 | 0.406 | 0.330 |
| 209016_s_at | Keratin 7 | KRT7 | 0.308 | 0.616 | 0.406 |
| 209008_x_at | Keratin 8 | KRT8 | 0.536 | 0.812 | 0.536 |
| 212119_at | Ras homolog gene family, member Q | RHOQ | 0.812 | 0.812 | 0.758 |
| 224793_s_at | Transforming growth factor, beta receptor I | TGFBR1 | 0.660 | 0.707 | 0.707 |
| 208944_at | Transforming growth factor, beta receptor II (70/80 kDa) | TGFBR2 | 1.000 | 0.707 | 0.707 |
| 218856_at | Tumor necrosis factor receptor superfamily, member 21 | TNFRSF21 | 0.379 | 0.467 | 0.536 |
| 210987_x_at* | Tropomyosin 1 (alpha) | TPM1 | 0.500 | 0.660 | 0.500 |
| 209118_s_at | Tubulin, alpha 3 | TUBA3 | 0.435 | 0.812 | 0.616 |
| 200931_s_at | Vinculin | VCL | 0.574 | 0.660 | 0.574 |
Note. Microarray results were filtered for probe sets downregulated in Matrigel samples for donor A, donor B, and donor C. Amount of fold change compared to control for each probe set is reported. An asterisk (*) denotes those genes which had multiple probe sets increased; a single representative probe set with fold changes with respect to control is reported.