Figure 1.

Impaired pulmonary function during PCP in SCID mice. For comparison of nonreconstituted and reconstituted SCID mice, time points are expressed in weeks after exposure to P. carinii. (a) Progressive decline in specific lung compliance and PaO₂ in nonreconstituted P. carinii–infected SCID mice. (b) Respiratory impairment and recovery after immune reconstitution of P. carinii–infected SCID mice. ND, not determined. C, P. carinii–free control. *P < 0.05 vs. P. carinii–free controls. **P < 0.05 vs. P. carinii–infected SCID mice at 9 weeks after exposure. ***P < 0.05 vs. reconstituted P. carinii–infected SCID mice at 32 DAR.