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Altered gene expression in hearts from MyBP-C(Neo) mice. Northern blots (a) show increased expression of α-skeletal actin and BNP mRNAs in comparison with GAPDH transcripts. Silver-stained SDS-page gels (b) demonstrate altered expression of cardiac MHC isoforms in total ventricular extracts from MyBP-C(Neo) mouse hearts (from 8–12-week-old animals; designated t/t) compared with protein from wild-type mice (+/+).
