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Five-year evolution of insulin-secretion profiles in 4 middle-aged carriers of the IPF-1 InsCCG243 mutation. The plots show comparisons of plasma glucose levels (Figure 3a), plasma insulin levels (Figure 3b), and insulin/glucose ratios (Figure 3c), between 1992 (filled bars) and 1997 (hatched bars), with the paired Student’s t test. Basal (0 minutes) and 2 hours (120 minutes) mean values (± SEM) during oral glucose tolerance tests are presented. *P = 0.02; **P = 0.011.
