Figure 4.

Segregation of the IPF-1 D76N variation in the 9 type 2 diabetic families in which it was detected. These families belong to a large collection, ascertained in France for the presence of at least 2 sibs presenting with overt type 2 diabetes, and additional family members were recruited, when available (ref. 16). Filled, half-filled, and open symbols represent subjects with overt type 2 diabetes mellitus, impaired glucose tolerance, and normal glucose tolerance, respectively. Under each symbol, the first line corresponds the actual age; the second line shows the age at diagnosis of overt type 2 diabetes (when appropriate). The third line shows individual BMI values (kg/m²), and the fourth line shows the genotype at IPF-1 codon 76 (italicized): N, Normal allele; M, mutant allele.