Figure 4.

Quantitative assessment of the airway epithelium for the percentage of exogenous CFTR mRNA (derived from the Ad_GVCFTR.10 vector) compared with endogenous CFTR mRNA (individual’s own CFTR gene expression) as a function of dose and time (baseline, days 3 and 30) after endobronchial spray of the first administration (cycle 1) of the Ad_GVCFTR.10 vector. The dashed line represents the 5% level of exogenous vector-derived CFTR mRNA. Each symbol represents a different individual (see Table 1). (a) Function of dose at day 3. (b) Function of time. The data for the 10⁶ and 10^6.5 doses (undetectable at each time point for all subjects) are not shown in b. “Pre” is before first vector administration.